Directed Differentiation Of Multipotential Human Neural Progenitor Cells To Astrocytes

Publications

The following includes a selection of recent publications from our lab. View the complete list here on PubMed.

 

Hyperpolarized [1-13C] glutamate: a metabolic imaging biomarker of IDH1 mutational status in glioma

Chaumeil MM, Larson PE, Woods SM, Cai L, Eriksson P, Robinson AE, Lupo JM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM.

Cancer Res. 2014 Aug 15; 74 (16): 4247-57. doi: 10.1158/0008-5472.CAN-14-0680. Epub 2014 May 29.
PubMed Link >

A subset of PARP inhibitors induces lethal telomere fusion in ALT-dependent tumor cells

Mukherjee J, Pandita A, Kamalakar C, Johannessen TC, Ohba S, Tang Y, Dalle- Ore CL, Bjerkvig R, Pieper RO.

Sci Transl Med. 2021 May 5; 13(592):eabc7211. DOI: 10.1126/scitranslmed.abc7211.

 

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PubMed Link >

Mutant IDH1 Expression Drives TERT Promoter Reactivation as Part of the Cellular Transformation Process

Ohba S, Mukherjee J, Johannessen TC, Mancini A, Chow TT, Wood M, Jones L, Mazor T, Marshall RE, Viswanath P, Walsh KM, Perry A, Bell RJ, Phillips JJ, Costello JF, Ronen SM, Pieper RO.

Cancer Res. 2016 Nov 15; 76 (22): 6680-6689. doi: 10.1158/0008-5472.CAN-16-0696. Epub 2016 Oct 6.
PubMed Link >

Lactate dehydrogenase A silencing in IDH mutant gliomas

Chesnelong C, Chaumeil MM, Blough MD, Al-Najjar M, Stechishin OD, Chan JA, Pieper RO, Ronen SM, Weiss S, Luchman HA, Cairncross JG.

Neuro Oncol. 2014; 16 (5): 686-95. doi: 10.1093/neuonc/not243. Epub 2013 Dec 22.
PubMed Link >

UBE2S, a novel substrate of Akt1, associates with Ku70 and regulates DNA repair and glioblastoma multiforme resistance to chemotherapy

Hu L, Li X, Liu Q, Xu J, Ge H, Wang Z, Wang H, Wang Z, Shi C, Xu X, Huang J, Lin Z, Pieper RO, Weng C.

Oncogene. 2017 Feb 23; 36 (8): 1145-1156. doi: 10.1038/onc.2016.281. Epub 2016 Sep 5.
PubMed Link >

Non-invasive in vivo assessment of IDH1 mutational status in glioma

Chaumeil MM, Larson PE, Yoshihara HA, Danforth OM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM.

Nat Commun. 2013; 4: 2429. doi: 10.1038/ncomms3429.
PubMed Link >

Rapid Conversion of Mutant IDH1 from Driver to Passenger in a Model of Human Gliomagenesis

Johannessen TA, Mukherjee J, Viswanath P, Ohba S, Ronen SM, Bjerkvig R, Pieper RO.

Mol Cancer Res. 2016 Mar 13; 14 (10): 976-983. Epub 2016 Jul 18.
PubMed Link >

Early Chk1 phosphorylation is driven by temozolomide-induced, DNA double strand break- and mismatch repair-independent DNA damage

Ito M, Ohba S, Gaensler K, Ronen SM, Mukherjee J, Pieper RO.

PLoS One. 2013 May 7; 8 (5): e62351. doi: 10.1371/journal.pone.0062351.
PubMed Link >

Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters

Viswanath P, Najac C, Izquierdo-Garcia JL, Pankov A, Hong C, Eriksson P, Costello JF, Pieper RO, Ronen SM.

Oncotarget. 2016 Jun 7; 7 (23): 34942-55. doi: 10.18632/oncotarget.9006.
PubMed Link >

Pyruvate kinase M2 expression, but not pyruvate kinase activity, is up-regulated in a grade-specific manner in human glioma

Mukherjee J, Phillips JJ, Zheng S, Wiencke J, Ronen SM, Pieper RO.

PLoS One. 2013; 8 (2): e57610. doi: 10.1371/journal.pone.0057610. Epub 2013 Feb 25.
PubMed Link >

PKM2 uses control of HuR localization to regulate p27 and cell cycle progression in human glioblastoma cells

Mukherjee J, Ohba S, See WL, Phillips JJ, Molinaro AM, Pieper RO.

Int J Cancer. 2016 Jul 1; 139 (1): 99-111. doi: 10.1002/ijc.30041. Epub 2016 Mar 2.
PubMed Link >

Evaluation of heterogeneous metabolic profile in an orthotopic human glioblastoma xenograft model using compressed sensing hyperpolarized 3D 13C magnetic resonance spectroscopic imaging

Park I, Hu S, Bok R, Ozawa T, Ito M, Mukherjee J, Phillips JJ, James CD, Pieper RO, Ronen SM, Vigneron DB, Nelson SJ.

Magn Reson Med. 2013; 70 (1): 33-9. doi: 10.1002/mrm.24434. Epub 2012 Jul 31.
PubMed Link >

IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism

Izquierdo-Garcia JL, Viswanath P, Eriksson P, Cai L, Radoul M, Chaumeil MM, Blough M, Luchman HA, Weiss S, Cairncross JG, Phillips JJ, Pieper RO, Ronen SM.

Cancer Res. 2015 Aug 1; 75 (15): 2999-3009. doi: 10.1158/0008-5472.CAN-15-0840. Epub 2015 Jun 4.
PubMed Link >

Longitudinal evaluation of MPIO-labeled stem cell biodistribution in glioblastoma using high resolution and contrast-enhanced MR imaging at 14.1 tesla

Chaumeil MM, Gini B, Yang H, Iwanami A, Sukumar S, Ozawa T, Pieper RO, Mischel PS, James CD, Berger MS, Ronen SM.

Neuro Oncol. 2012; 14 (8): 1050-61. doi: 10.1093/neuonc/nos126. Epub 2012 Jun 4.
PubMed Link >

HDAC inhibition in glioblastoma monitored by hyperpolarized 13 C MRSI

Radoul M, Najac C, Viswanath P, Mukherjee J, Kelly M, Gillespie AM, Chaumeil MM, Eriksson P, Delos Santos R, Pieper RO, Ronen SM.

NMR Biomed. 2019; 32 (2): e4044. doi: 10.1002/nbm.4044. Epub 2018 Dec 18.
PubMed Link >