Directed Differentiation Of Multipotential Human Neural Progenitor Cells To Astrocytes

Publications

The following includes a selection of recent publications from our lab. View the complete list here on PubMed.

 

IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism

Izquierdo-Garcia JL, Viswanath P, Eriksson P, Cai L, Radoul M, Chaumeil MM, Blough M, Luchman HA, Weiss S, Cairncross JG, Phillips JJ, Pieper RO, Ronen SM.

Cancer Res. 2015 Aug 1; 75 (15): 2999-3009. doi: 10.1158/0008-5472.CAN-15-0840. Epub 2015 Jun 4.
PubMed Link >

Longitudinal evaluation of MPIO-labeled stem cell biodistribution in glioblastoma using high resolution and contrast-enhanced MR imaging at 14.1 tesla

Chaumeil MM, Gini B, Yang H, Iwanami A, Sukumar S, Ozawa T, Pieper RO, Mischel PS, James CD, Berger MS, Ronen SM.

Neuro Oncol. 2012; 14 (8): 1050-61. doi: 10.1093/neuonc/nos126. Epub 2012 Jun 4.
PubMed Link >

HDAC inhibition in glioblastoma monitored by hyperpolarized 13 C MRSI

Radoul M, Najac C, Viswanath P, Mukherjee J, Kelly M, Gillespie AM, Chaumeil MM, Eriksson P, Delos Santos R, Pieper RO, Ronen SM.

NMR Biomed. 2019; 32 (2): e4044. doi: 10.1002/nbm.4044. Epub 2018 Dec 18.
PubMed Link >

Metabolic reprogramming in mutant IDH1 glioma cells

Izquierdo-Garcia JL, Viswanath P, Eriksson P, Chaumeil MM, Pieper RO, Phillips JJ, Ronen SM.

PLoS One. 2015 Feb 23; 10 (2): e0118781. doi: 10.1371/journal.pone.0118781. eCollection 2015.
PubMed Link >

Sensitivity of glioblastomas to clinically available MEK inhibitors is defined by neurofibromin 1 deficiency

See WL, Tan IL, Mukherjee J, Nicolaides T, Pieper RO.

Cancer Res. 2012 Jul 1; 72 (13): 3350-9. doi: 10.1158/0008-5472.CAN-12-0334. Epub 2012 May 9.
PubMed Link >

Neurofibromin knockdown in glioma cell lines is associated with changes in cytokine and chemokine secretion in vitro

Wood MD, Mukherjee J, Pieper RO.

Sci Rep. 2018 Apr 11; 8 (1): 5805. doi: 10.1038/s41598-018-24046-2.
PubMed Link >

Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells

Park I, Mukherjee J, Ito M, Chaumeil MM, Jalbert LE, Gaensler K, Ronen SM, Nelson SJ, Pieper RO.

Cancer Res. 2014 Dec 1; 74 (23): 7115-24. doi: 10.1158/0008-5472.CAN-14-0849. Epub 2014 Oct 15.
PubMed Link >

NPAS3 demonstrates features of a tumor suppressive role in driving the progression of Astrocytomas

Moreira F, Kiehl TR, So K, Ajeawung NF, Honculada C, Gould P, Pieper RO, Kamnasaran D.

Am J Pathol. 2011; 179 (1): 462-76. doi: 10.1016/j.ajpath.2011.03.044. Epub 2011 May 19.
PubMed Link >

Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner

Viswanath P, Radoul M, Izquierdo-Garcia JL, Luchman HA, Gregory Cairncross J, Pieper RO, Phillips JJ, Ronen SM.

Cancer Metab. 2018 Apr 3; 6: 3. doi: 10.1186/s40170-018-0178-3. eCollection 2018.
PubMed Link >

Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase

Izquierdo-Garcia JL, Cai LM, Chaumeil MM, Eriksson P, Robinson AE, Pieper RO, Phillips JJ, Ronen SM.

PLoS One. 2014 Sep 22; 9 (9): e108289. doi: 10.1371/journal.pone.0108289. eCollection 2014.
PubMed Link >

Downregulation of FIP200 induces apoptosis of glioblastoma cells and microvascular endothelial cells by enhancing Pyk2 activity

Wang D, Olman MA, Stewart J Jr, Tipps R, Huang P, Sanders PW, Toline E, Prayson RA, Lee J, Weil RJ, Palmer CA, Gillespie GY, Liu WM, Pieper RO, Guan JL, Gladson CL.

PLoS One. 2011; 6 (5): e19629. doi: 10.1371/journal.pone.0019629. Epub 2011 May 13.
PubMed Link >

Mutant IDH1 Cooperates with ATRX Loss to Drive the Alternative Lengthening of Telomere Phenotype in Glioma

Mukherjee J, Johannessen TC, Ohba S, Chow TT, Jones L, Pandita A, Pieper RO.

Cancer Res. 2018 Jun 1; 78 (11): 2966-2977. doi: 10.1158/0008-5472.CAN-17-2269. Epub 2018 Mar 15.
PubMed Link >

Mutant IDH1-driven cellular transformation increases RAD51-mediated homologous recombination and temozolomide resistance

Ohba S, Mukherjee J, See WL, Pieper RO.

Cancer Res. 2014 Sep 1; 74 (17): 4836-44. doi: 10.1158/0008-5472.CAN-14-0924. Epub 2014 Jul 17.
PubMed Link >

Phosphoglycerate Mutase 1 Activates DNA Damage Repair via Regulation of WIP1 Activity

Ohba S, Johannessen TA, Chatla K, Yang X, Pieper RO, Mukherjee J.

Cell Rep. 2020 Apr 14; 31 (2): 107518. doi: 10.1016/j.celrep.2020.03.082.
PubMed Link >

2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas

Viswanath P, Radoul M, Izquierdo-Garcia JL, Ong WQ, Luchman HA, Cairncross JG, Huang B, Pieper RO, Phillips JJ, Ronen SM.

Cancer Res. 2018 May 1; 78 (9): 2290-2304. doi: 10.1158/0008-5472.CAN-17-2926. Epub 2018 Jan 22.
PubMed Link >