Directed Differentiation Of Multipotential Human Neural Progenitor Cells To Astrocytes

Publications

The following includes a selection of recent publications from our lab. View the complete list here on PubMed.

 

Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase

Izquierdo-Garcia JL, Cai LM, Chaumeil MM, Eriksson P, Robinson AE, Pieper RO, Phillips JJ, Ronen SM.

PLoS One. 2014 Sep 22; 9 (9): e108289. doi: 10.1371/journal.pone.0108289. eCollection 2014.
PubMed Link >

Downregulation of FIP200 induces apoptosis of glioblastoma cells and microvascular endothelial cells by enhancing Pyk2 activity

Wang D, Olman MA, Stewart J Jr, Tipps R, Huang P, Sanders PW, Toline E, Prayson RA, Lee J, Weil RJ, Palmer CA, Gillespie GY, Liu WM, Pieper RO, Guan JL, Gladson CL.

PLoS One. 2011; 6 (5): e19629. doi: 10.1371/journal.pone.0019629. Epub 2011 May 13.
PubMed Link >

Mutant IDH1 Cooperates with ATRX Loss to Drive the Alternative Lengthening of Telomere Phenotype in Glioma

Mukherjee J, Johannessen TC, Ohba S, Chow TT, Jones L, Pandita A, Pieper RO.

Cancer Res. 2018 Jun 1; 78 (11): 2966-2977. doi: 10.1158/0008-5472.CAN-17-2269. Epub 2018 Mar 15.
PubMed Link >

Mutant IDH1-driven cellular transformation increases RAD51-mediated homologous recombination and temozolomide resistance

Ohba S, Mukherjee J, See WL, Pieper RO.

Cancer Res. 2014 Sep 1; 74 (17): 4836-44. doi: 10.1158/0008-5472.CAN-14-0924. Epub 2014 Jul 17.
PubMed Link >

Phosphoglycerate Mutase 1 Activates DNA Damage Repair via Regulation of WIP1 Activity

Ohba S, Johannessen TA, Chatla K, Yang X, Pieper RO, Mukherjee J.

Cell Rep. 2020 Apr 14; 31 (2): 107518. doi: 10.1016/j.celrep.2020.03.082.
PubMed Link >

2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas

Viswanath P, Radoul M, Izquierdo-Garcia JL, Ong WQ, Luchman HA, Cairncross JG, Huang B, Pieper RO, Phillips JJ, Ronen SM.

Cancer Res. 2018 May 1; 78 (9): 2290-2304. doi: 10.1158/0008-5472.CAN-17-2926. Epub 2018 Jan 22.
PubMed Link >

Hyperpolarized [1-13C] glutamate: a metabolic imaging biomarker of IDH1 mutational status in glioma

Chaumeil MM, Larson PE, Woods SM, Cai L, Eriksson P, Robinson AE, Lupo JM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM.

Cancer Res. 2014 Aug 15; 74 (16): 4247-57. doi: 10.1158/0008-5472.CAN-14-0680. Epub 2014 May 29.
PubMed Link >

A subset of PARP inhibitors induces lethal telomere fusion in ALT-dependent tumor cells

Mukherjee J, Pandita A, Kamalakar C, Johannessen TC, Ohba S, Tang Y, Dalle- Ore CL, Bjerkvig R, Pieper RO.

Sci Transl Med. 2021 May 5; 13(592):eabc7211. DOI: 10.1126/scitranslmed.abc7211.

 

Abstract >

 

Reprint >

 

Full Text >

PubMed Link >

Mutant IDH1 Expression Drives TERT Promoter Reactivation as Part of the Cellular Transformation Process

Ohba S, Mukherjee J, Johannessen TC, Mancini A, Chow TT, Wood M, Jones L, Mazor T, Marshall RE, Viswanath P, Walsh KM, Perry A, Bell RJ, Phillips JJ, Costello JF, Ronen SM, Pieper RO.

Cancer Res. 2016 Nov 15; 76 (22): 6680-6689. doi: 10.1158/0008-5472.CAN-16-0696. Epub 2016 Oct 6.
PubMed Link >

Lactate dehydrogenase A silencing in IDH mutant gliomas

Chesnelong C, Chaumeil MM, Blough MD, Al-Najjar M, Stechishin OD, Chan JA, Pieper RO, Ronen SM, Weiss S, Luchman HA, Cairncross JG.

Neuro Oncol. 2014; 16 (5): 686-95. doi: 10.1093/neuonc/not243. Epub 2013 Dec 22.
PubMed Link >

UBE2S, a novel substrate of Akt1, associates with Ku70 and regulates DNA repair and glioblastoma multiforme resistance to chemotherapy

Hu L, Li X, Liu Q, Xu J, Ge H, Wang Z, Wang H, Wang Z, Shi C, Xu X, Huang J, Lin Z, Pieper RO, Weng C.

Oncogene. 2017 Feb 23; 36 (8): 1145-1156. doi: 10.1038/onc.2016.281. Epub 2016 Sep 5.
PubMed Link >

Non-invasive in vivo assessment of IDH1 mutational status in glioma

Chaumeil MM, Larson PE, Yoshihara HA, Danforth OM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM.

Nat Commun. 2013; 4: 2429. doi: 10.1038/ncomms3429.
PubMed Link >

Rapid Conversion of Mutant IDH1 from Driver to Passenger in a Model of Human Gliomagenesis

Johannessen TA, Mukherjee J, Viswanath P, Ohba S, Ronen SM, Bjerkvig R, Pieper RO.

Mol Cancer Res. 2016 Mar 13; 14 (10): 976-983. Epub 2016 Jul 18.
PubMed Link >

Early Chk1 phosphorylation is driven by temozolomide-induced, DNA double strand break- and mismatch repair-independent DNA damage

Ito M, Ohba S, Gaensler K, Ronen SM, Mukherjee J, Pieper RO.

PLoS One. 2013 May 7; 8 (5): e62351. doi: 10.1371/journal.pone.0062351.
PubMed Link >

Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters

Viswanath P, Najac C, Izquierdo-Garcia JL, Pankov A, Hong C, Eriksson P, Costello JF, Pieper RO, Ronen SM.

Oncotarget. 2016 Jun 7; 7 (23): 34942-55. doi: 10.18632/oncotarget.9006.
PubMed Link >